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In 2020, the White House released the “Call to Action to the Tech Community on New Machine Readable COVID-19 Dataset,” wherein artificial intelligence experts are asked to collect data and develop text mining techniques that can help the science community answer high-priority scientific questions related to COVID-19. The Allen Institute for AI and collaborators announced the availability of a rapidly growing open dataset of publications, the COVID-19 Open Research Dataset (CORD-19). As the pace of research accelerates, biomedical scientists struggle to stay current. To expedite their investigations, scientists leverage hypothesis generation systems, which can automatically inspect published papers to discover novel implicit connections. We present automated general purpose hypothesis generation systems AGATHA-C and AGATHA-GP for COVID-19 research. The systems are based on the graph mining and transformer models. The systems are massively validated using retrospective information rediscovery and proactive analysis involving human-in-the-loop expert analysis. Both systems achieve high-quality predictions across domains in fast computational time and are released to the broad scientific community to accelerate biomedical research. In addition, by performing the domain expert curated study, we show that the systems are able to discover ongoing research findings such as the relationship between COVID-19 and oxytocin hormone.All code, details, and pre-trained models are available at https://github.com/IlyaTyagin/AGATHA-C-GP. 

HYPERGRAPHS provide the formalism needed to solve problems consisting of interconnected item sets. Similar to a traditional graph, the hypergraph has the added generalization that “hyperedges” may connect any number of nodes. Domains such as very-large-scale integration for creating integrated circuits [1], machine learning [2], [3], [4], parallel algorithms [5], combinatorial scientific computing [6], and social network analysis [7], [8] all contain significant and challenging instances of hypergraph problems. One important problem, Hypergraph partitioning, involves dividing the nodes of a hypergraph among k similarly-sized disjoint sets while reducing the number of hyperedges that span multiple partitions. In the context of load balancing, this is the problem of dividing logical threads (nodes) that share data dependencies (hyperedges) among available machines (partitions) in order to balance the number of threads per machine and minimize communication overhead. However, hypergraph partitioning is both NP-Hard to solve [9] and approximate [10]. 

Medical research is risky and expensive. Drug discovery requires researchers to efficiently winnow thousands of potential targets to a small candidate set. However, scientists spend significant time and money long before seeing the intermediate results that ultimately determine this smaller set. Hypothesis generation systems address this challenge by mining the wealth of publicly available scientific information to predict plausible research directions.We present AGATHA, a deep-learning hypothesis generation system that learns a data-driven ranking criteria to recommend new biomedical connections. We massively validate our system with a temporal holdout wherein we predict connections first introduced after 2015 using data published beforehand. We additionally explore biomedical sub-domains, and demonstrate AGATHA’s predictive capacity across the twenty most popular relationship types. Furthermore, we perform an ablation study to examine the aspects of our semantic network that most contribute to recommendation quality. Overall, AGATHA achieves best-in-class recommendation quality when compared to other hypothesis generation systems built to predict across all available biomedical literature. Reproducibility: All code, experimental data, and pre-trained models are available online: sybrandt.com/2020/agatha.